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OCR: massive Prader- Willi syndrome is characterised et. a obesity, short stature, small hands and f land distinctive face with almond-shaped eye l activity postnatal hypotonia following poor foet (Fig. 13.24). bme Behavioural abnormalities in this synd include development delay and emotion er-Willi instability. There is an association of Pra syndrome with delayed puberty due to may hypothalamic dysfunction. Affected boy e to the appear to have a microphallus, partly du s which trophic increased fat pad at the base of the phall 'buries' the penis, although hypogonad ause hypogonadism may also be present and erance decreased phallic size. Carbohydrate into y related tooccurs in Prader-Willi syndrome, possib f affected the massive obesity. Up to fifty per cent he long patients have an interstitia ...